恒瑞医疗 网址: www.hrmedical.com.cn

专业文献

三氧化二砷经callispheres载药微球/碘油乳剂肝动脉化疗栓塞术在兔肝癌模型中的药代动力学和瘤内药物浓度的比较研究 -ag捕鱼平台

文字: 2020-6-15    浏览次数:345    


abstract

the objective of this study was to investigate the plasma pharmacokinetic profiles, intratumoral concentration and tissue distribution of arsenic trioxide (ato) by drug-eluting beads (deb)-transcatheter arterial chemoembolization (tace) compared with conventional tace (ctace) in a rabbit liver tumor model.

本研究的目的是探讨三氧化二砷(ato)经载药微球经导管动脉化疗栓塞术(deb-tace)与传统经导管动脉化疗栓塞术(ctace)在兔肝癌模型中的药代动力学、药物瘤内浓度及组织分布。


sixty-four rabbits with vx2 liver tumor were established and randomly assigned to four groups equally. the callispheres microspheres (csm)-ato group received deb-tace treatment using ato-loaded csm; the ctace-ato group received ctace treatment using ato mixed with lipiodol; the csm-normal control (nc) group received deb-tace treatment using blank csm; the tae-lipiodol group received ctace treatment using saline mixed with lipiodol. ato concentration in plasma, tumor and normal tissues, and liver and kidney function indexes were evaluated.

建立64只vx2肝肿瘤兔模型,随机分为4组。a组使用加载了三氧化二砷的callispheres载药微球进行tace治疗;b组使用混合了三氧化二砷的碘油进行tace治疗;c组使用无载药的空白callispheres微球进行tace治疗;d组使用混合了生理盐水的碘油进行tace治疗。测定血浆、肿瘤组织、正常组织中三氧化二砷浓度及肝肾功能指标。


the csm-ato group exhibited lower plasma ato concentrations at 10 minutes and 20 minutes post treatment compared with the ctace-ato group. meanwhile, intratumoral ato concentrations were higher in the csm-ato group compared with the ctace-ato group at 3-,7- and 14-days post treatment. in normal liver tissue, heart and muscle tissues, ato concentrations between the csm-ato and ctace groups were similar at each time point; in kidney and lung tissues, ato concentrations were lower in the csm-ato group at 1-day post treatment while they were similar at 3, 7 and 14 days post treatment. also, liver or kidney function indexes were of no difference at each time point between csm-ato and ctace-ato groups.

与b组相比,a组在治疗后10分钟和20分钟时血浆三氧化二砷浓度较低。同时,a组瘤内三氧化二砷浓度高于治疗后3、7和14天的b组。在正常肝组织、心脏和肌肉组织中,a组和b组在各时间点的三氧化二砷浓度相似; 在肾脏和肺组织中,a组在治疗后1天的三氧化二砷浓度较低,而在治疗后3、7和14天的三氧化二砷浓度相似。a组与b组各时间点肝肾功能指标无差异。


administration of ato via deb-tace decreases systemic concentration while increasing intratumoral concentration of ato without increasing liver or kidney toxicity compared with ctace.

与ctace相比,deb-tace可降低三氧化二砷的全身浓度,同时增加三氧化二砷的瘤内浓度,而不增加肝肾毒性。


丨本文译者魏宁

中国科学技术大学附属第一医院(安徽省省立医院) 介入放射科

原文链接:https://mp.weixin.qq.com/s/kscxklqg07ag0ffwrsgwgg