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应用载药微球行经导管肝动脉化疗栓塞术治疗肝细胞癌术后发生疼痛的危险因素测定 -ag捕鱼平台

文字: 2020-6-9    浏览次数:339    

abstract

to identify risk factors for pain after transarterial chemoembolization with drugeluting beads (deb-tace) for hepatocellular carcinoma (hcc).

为探讨应用载药微球行经导管肝动脉化疗栓塞术(tace)治疗肝细胞癌(hcc)术后发生疼痛的危险因素。


in this retrospective study, a total of 118 consecutive patients who underwent deb-tace between june 2016 and may 2019 with post-tace pain were included. the patients were divided into three groups based on the severity of post-tace pain according to the distribution of pain visual analogue scale/score (vas). potential risk factors for post-tace pain were primarily analyzed using the chi-square test, one-way analysis of variance, or kruskal–wallis test (if appropriate). for multivariate analysis, an ordinal logistic regression model was utilized. variables with p<0.10 in the univariate analysis were included in a multivariate model to identify independent risk factors for post-tace pain. amultivariate analysis was also performed by means of a decision tree using the classification and regression tree (cart) algorithm.

该回顾性研究纳入2016年6月至2019年5月期间行载药微球tace术后发生疼痛的118名患者进行分析。根据视觉模拟评分法(vas)将这些患者tace术后发生疼痛的严重程度分为三组,tace术后疼痛的潜在危险因素主要采用卡方检验、单因素方差分析或kruskal-wallis检验(如适用)进行分析。多变量分析采用有序逻辑回归模型。将单变量分析中p<0.10的变量纳入多变量模型,以确定tace术后疼痛的独立危险因素。采用分类回归树(cart)算法,通过决策树进行无变量分析。


the univariate analysis showed that elderly patients or patients with portal venous tumor thrombus (pvtt) were more likely to have severe post-tace pain than young patients or those without pvtt (p=0.028 and <0.001, respectively). however, in the ordinal logistic regression, nonsuperselective chemoembolization and presence of pvtt were independent risk factors of severe post-tace pain (p=0.046 and <0.001, respectively). in addition, the cart showed that nonsuperselective chemoembolization and pvtt could increase the probability of severe post-tace pain.

单因素分析显示,老年患者或存在门静脉瘤栓(pvtt)患者较年轻患者或无pvtt患者更容易出现tace术后严重疼痛(p=0.028, p<0.001)。而在有序逻辑回归中,未超选择性的化疗栓塞和存在pvtt是tace术后出现严重疼痛的独立危险因素(p=0.046和<0.001)。此外,cart显示未超选择性的化疗栓塞和存在pvtt可增加tace术后出现严重疼痛的可能性。


nonsuperselective chemoembolization and pvtt are independent risk factors for pain after deb-tace. therefore, these factors should be taken into full consideration for the relief of pain.

未超选择性的化疗栓塞和存在pvtt是载药微球tace术后出现疼痛的独立危险因素。因此,为缓解疼痛应充分考虑这些因素。


丨本文译者杨天顾

青岛大学附属医院 介入科

原文链接:https://mp.weixin.qq.com/s/gxba3pubfenzmrrolnojfa