恒瑞医疗 网址: www.hrmedical.com.cn

专业文献

callispheres®载药微球化疗栓塞与传统化疗栓塞在治疗肝癌的比较:一项多中心回顾性研究 -ag捕鱼平台

文字: 2020-5-25    浏览次数:350    

this study aimed to compare the efficacy and safety between transarterial chemoembolization (tace) with callispheres® microspheres (csm-tace) and conventional tace (ctace) in patients with hepatocellular carcinoma (hcc).

本研究旨在比较callispheres®载药微球化疗栓塞(csm-tace)和常规经动脉化疗栓塞 (ctace)治疗肝癌(hcc)的疗效和安全性。


three hundred and thirty-five hcc patients receiving csm-tace or ctace were consecutively enrolled in this multi-center, retrospective cohort study, and then divided into csm-tace group and ctace group accordingly. complete response (cr), objective response (orr) and disease control response (dcr) was assessed according to mrecist criteria at 1 month (m1), 3 months(m3) and 6 months(m6) after treatment. progression-free survival (pfs) and overall survival (os) were assessed. liver function indexes and adverse events (aes) were also evaluated.

在本项多中心回顾性队列研究中,我们连续纳入了335例接受csm-tace或ctace治疗的hcc患者,并将其分为csm-tace组和ctace组。在治疗后1个月(m1)、3个月(m3)和6个月(m6),根据mrecist标准评估完全缓解(cr)、客观缓解(orr)和疾病控制缓解(dcr)。评估无进展生存期(pfs)和总生存期(os)以及肝功能指标和不良事件(aes)。


cr at m3 (p=0.020) and orr at m1 (p<0.001), m3 (p<0.001) and m6 (p=0.017) after treatment were significantly higher in the csm-tace compared with ctace group. dcrs, pfs (25.3 months vs 24.2 months, p=0.503) and os (27.8 months vs 25.3 months, p=0.203) were similar between the two groups. csm-tace was independently correlated with higher orr at m1 (p=0.002) and longer os (p=0.023). abnormal alkaline phosphatase (alp) (p=0.049) was independently associated with lower orr at m3, and history of alcohol intake (p=0.019) and largest nodule size ≥7 cm (p=0.015) independently correlated with lower orr at m6 (p=0.015). largest nodule size ≥7 cm (p=0.029) and abnormal albumin (alb) (p=0.046) were independently associated with shorter pfs. child-pugh stage b/c (p=0.023), abnormal alb (p=0.001), alp (p=0.008) and alpha-fetoprotein (afp) (p=0.005) were independently associated with shorter os. most liver function indexes and aes were similar between the two groups (p>0.05), except that alp (p=0.005), total bilirubin (p=0.031), pain during procedure (p=0.034) and occurrence of fever post(treatment (p=0.017) were significantly elevated in the csm-tace compared with ctace group.

csm-tace组治疗后m3 (p=0.020) cr、m1 (p<0.001)、m3 (p<0.001)、m6 (p=0.017)的 orr明显高于ctace组。两组间dcrs、pfs(25.3个月vs 24.2个月,p=0.503)、os(27.8个月vs 25.3个月,p=0.203)比较接近。csm-tace与m1的orr (p=0.002) 独立相关,而且具有更长的os (p=0.023)。异常碱性磷酸酶(alp) (p=0.049)与m3时较低的orr,酒精摄入史(p=0.019),最大结节≥7cm (p=0.015)以及m6时较低的orr独立相关(p=0.015)。最大结节≥7cm (p=0.029)和异常白蛋白(alb) (p=0.046)与较短的pfs独立相关。child-pugh期b/c (p=0.023)、alb异常(p=0.001)、alp (p=0.008)和甲胎蛋白(afp) (p=0.005)分别与较短os相关。除了csm-tace组患者alp (p=0.005)、总胆红素(p=0.031)、术中疼痛(p=0.034)、治疗后发热(p=0.017)明显高于ctace组(p=0.017)外,两组患者肝功能指标及aes基本相似(p>0.05)。


csm-tace presents with a better treatment response and similar survival profile compared with ctace in hcc patients.

与ctace相比,csm-tace在hcc患者中具有更好的治疗效果和相似的生存情况。 

中国科学技术大学附属第一医院(安徽省省立医院) 介入放射科

原文链接:https://mp.weixin.qq.com/s/_jmhhvfqqqsnormlus9zxg