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callispheres®微球经动脉化疗栓塞治疗中国肝细胞癌患者的疗效、安全性及预后因素-ag捕鱼平台

文字: 2020-2-5    浏览次数:381    

callispheres®微球经动脉化疗栓塞治疗中国肝细胞癌患者的疗效、安全性及预后因素

background丨
we aimed to investigate treatment response, survival profiles, safety profiles, and predictive factors of drug-eluting beads-transarterial chemoembolization(deb-tace) with callispheres® microspheres (csm) in treating chinese hepatocellular carcinoma (hcc) patients.

背景丨

我们的研究旨在分析callispheres®微球(csm)经动脉化疗栓塞(deb-tace)治疗中国肝细胞癌(hcc)患者的疗效、生存情况、安全性及预后因素。


methods丨
a total of 66 hcc patients about to receive deb-tace with csm therapy were consecutively enrolled in this prospective cohort study. treatment response was recorded. besides, progression-free survival (pfs) and overall survival (os) were also recorded. all adverse events including pain, nausea, vomiting, fever, and liver function damage were recorded during hospitalization.

方法丨

本前瞻性队列研究连续纳入66例即将接受csm deb-tace治疗的hcc患者。记录治疗反应、无进展生存(pfs)和总生存(os)。记录住院期间的所有不良事件(aes),包括疼痛、恶心、呕吐、发烧和肝功能损害


results丨
37.9% of patients achieved complete response (cr) and 81.8% of patients achieved an objective response rate (orr). for survival, mean pfs and os were 13.7 (11.7-15.8) months and 18.8 (95% ci: 16.3-21.2) months, respectively. multivariate logistic regression analysis revealed that a number of nodules ≥2 was an independent factor for worse cr; moreover, multivariate cox's regression analysis disclosed that largest sample size ≥5 cm was an independent factor for shorter pfs, and child-pugh b and bclc stage b/c were independent predictive factors for unfavorable os. as to aes, numbers of patients suffered liver function damage, pain, nausea, vomiting, and fever were 29 (43.9%), 27 (40.9%), 22 (33.3%), 13 (19.7%), and 37 (56.1%), respectively.

结果丨

37.9%的患者达到完全缓解(cr),81.8%的患者达到客观缓解(orr)。生存方面,pfs和os分别为13.7个月(95%ci:11.7-15.8)和18.8个月(95%ci:16.3-21.2)。多因素logistic回归分析显示,结节数≥2是cr较差的独立预测因素;多变量cox回归分析显示,最大结节≥5cm是pfs较短的独立预测因素,child-pugh b级和bclc b/c期是os不佳的独立预测因素。aes方面,肝功能损害、疼痛、恶心、呕吐、发热患者数分别为29例(43.9%)、27例(40.9%)、22例(33.3%)、13例(19.7%)、37例(56.1%)。


conclusion丨
drug-eluting beads-transarterial chemoembolization with csm is an effective and tolerated treatment for chinese hcc patients, and number of nodules≥2, largest nodule size≥5 cm, child-pugh stage b, and bclc stage b/c correlates with unfavorable prognosis.

结论丨

对于中国hcc患者,csm载药微球经动脉化疗栓塞是一种有效且耐受性良好的治疗方式,并且结节数≥2、最大结节≥5 cm、child-pugh b级、bclc b/c期与预后不良相关。

原文链接:https://mp.weixin.qq.com/s/ksljlewg3tbm6dp4bi3d8a