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干预后的(非预处理或动态变化的)白介素-ag捕鱼平台

文字: 2019-12-17    浏览次数:388    


background: the aim of this study was to determine the potential prognostic roles of the perioperative interleukin-6 (il-6) level and its dynamic changes in patients with hepatocellular carcinoma (hcc) undergoing transarterial chemoembolization (tace).

背景:本研究旨在确定肝细胞癌(hcc)患者经动脉化疗栓塞(tace)围手术期白介素-6 (il-6)水平及其动态变化潜在的预后作用。

 

materials and methods: sixty patients with hepatitis b virus-associated hcc receiving tace were enrolled in the study. serum il-6 levels were determined at baseline and 1 day after tace by immunoassay. response to tace was evaluated after a 4-6-week interval. factors associated with tumor response were analyzed by univariate and multivariate analysis in a cox regression model. receiver operating characteristic (roc) curve analysis was performed to assess the predictive performance of the included variables on tumor response in patients with hcc undergoing tace.

材料与方法:共有60例乙肝病毒相关的hcc患者接受tace治疗。血清il-6水平分别于基线和tace术后1天进行免疫测定。4-6周后评估tace反应。在cox回归模型中,采用单变量和多变量法分析与肿瘤反应相关的因素。受试者工作特性(roc)曲线评估纳入变量对hcc tace患者肿瘤反应的预测效果。

 

results: the serum il-6 level was significantly elevated 1 day after tace. patients in the low postintervention il-6 level group had a high probability of achieving an objective response (or) (66.7% vs. 18.8%, p = .021). post-tace il-6 level (≤12.7 pg/ml) and post-/pre-tace neutrophils ratio (>2.47) were independently correlated with or after tace. roc curve analysis showed that a combined index based on those two factors exhibited optimal predictive power of tumor response among all the included variables (area under the curve = 0.740, 95% confidence interval: 0.601-0.879). additionally, high post-tace plasma il-6 level was associated with maximum tumor size, vascular invasion, post-tace aspartate aminotransferase, and barcelona clinic liver cancer stage.

结果tace术后1天血清il-6水平明显升高。干预后il-6水平较低的患者达到客观缓解(or)的几率较高(66.7% vs. 18.8% p = .021)tace术后il-6水平(≤12.7 pg/ml) tace术后/术前中性粒细胞比率(>2.47)tace术后or独立相关。roc曲线分析显示,在纳入的所有变量中(曲线下面积= 0.740,95%ci:0.601-0.879),基于这两个因素的综合指数对肿瘤反应的预测力最佳。此外,tace术后血浆il-6高水平与最大肿瘤体积、血管侵犯、tace术后天冬氨酸转氨酶和巴塞罗那临床肝癌分期相关。

 

conclusion: our study suggests that the post-treatment serum il-6 level, rather than pretreatment or dynamic changes of il-6, serves as a powerful predictor for tumor response. these findings provide evidence to help discriminate between patients who will particularly benefit from tace and those who require more personalized therapeutic regimens and rigorous surveillance.

结论:我们的研究表明,治疗后的血清il-6水平,而不是预处理或动态变化的il-6,是预测肿瘤反应的一种较强的预测因子。这一发现为区分哪些患者将特别受益于tace治疗,以及哪些患者需要更加个性化的治疗方案和严格的监测提供了依据。