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载药微球经动脉化疗栓塞 vs. 同步放化疗治疗宫颈癌的短期疗效、安全性和成本效益-ag捕鱼平台

文字: 2019-11-13    浏览次数:511    

objectiveto investigate the short-term efficacy and safety of transarterial chemoembolization with drug-eluting beads (deb-tace) versus synchronous radiochemotherapy among women with cervical cancer.

目的:探讨载药微球经动脉化疗栓塞(deb-tace) vs. 同步放化疗在宫颈癌患者中的短期疗效和安全性。

 

methodsa retrospective cohort study of women treated by synchronous radiochemotherapy (n=20) and deb-tace (n=20) at a single center in china between november 2015 and september 2017. inclusion criteria were pathologic diagnosis of cervical cancer, age at least 18 years, and complete clinicopathologic information. hospital stay, direct medical cost, resection frequency, adverse events, treatment responses, progression-free survival (pfs) and overall survival (os) were compared between treatments.

方法:对201511月至20179月在中国某单中心接受同步放化疗(n=20)deb-tace (n=20)治疗的女性进行回顾性队列分析。纳入标准:病理诊断为宫颈癌,年龄至少为18岁,临床病理资料完整。比较两组患者的住院时间、直接医疗费用、手术切除频率、不良事件、治疗反应、无进展生存期(pfs)和总生存期(os)

 

resultsthere was no difference in treatment responses, pfs, or os between the two groups. hospital stay was shorter, direct medical costs were lower, and resection rate was higher in the deb-tace group than in the radiochemotherapy group (all p<0.05). in univariate and multivariate logistic regression analysis, no factor was associated with complete response. no predictive factor for pfs or os was identified by cox proportional regression analysis. fewer adverse advents were recorded in the deb-tace group than in the synchronous radiochemotherapy group.  

结果:两组治疗反应、pfsos均无明显差异。与放化疗组相比,deb-tace组住院时间更短,直接医疗费用更低,达到可切除标准的患者比例更高 (均为p<0.05)。在单因素和多因素logistic回归分析中,没有任何因素与完全反应有关。cox比例回归分析未发现pfsos的预测因素。与同步放化疗组相比,deb-tace组的不良反应更少。

 

conclusionamong women with cervical cancer, deb-tace achieved equal short-term efficacy, better tolerance, less hospital stay and medical costs, and higher resection rates as compared with synchronous radiochemotherapy.

结论:在宫颈癌患者中,deb-tace与同步放化疗短期疗效相同,耐受性更好,住院时间更短,医疗费用更少,实现可切除的患者比例更高。