载药微球经动脉化疗栓塞 vs. 同步放化疗治疗宫颈癌的短期疗效、安全性和成本效益-ag捕鱼平台
objective：to investigate the short-term efficacy and safety of transarterial chemoembolization with drug-eluting beads (deb-tace) versus synchronous radiochemotherapy among women with cervical cancer.
目的：探讨载药微球经动脉化疗栓塞(deb-tace) vs. 同步放化疗在宫颈癌患者中的短期疗效和安全性。
methods：a retrospective cohort study of women treated by synchronous radiochemotherapy (n=20) and deb-tace (n=20) at a single center in china between november 2015 and september 2017. inclusion criteria were pathologic diagnosis of cervical cancer, age at least 18 years, and complete clinicopathologic information. hospital stay, direct medical cost, resection frequency, adverse events, treatment responses, progression-free survival (pfs) and overall survival (os) were compared between treatments.
results：there was no difference in treatment responses, pfs, or os between the two groups. hospital stay was shorter, direct medical costs were lower, and resection rate was higher in the deb-tace group than in the radiochemotherapy group (all p<0.05). in univariate and multivariate logistic regression analysis, no factor was associated with complete response. no predictive factor for pfs or os was identified by cox proportional regression analysis. fewer adverse advents were recorded in the deb-tace group than in the synchronous radiochemotherapy group.
conclusion：among women with cervical cancer, deb-tace achieved equal short-term efficacy, better tolerance, less hospital stay and medical costs, and higher resection rates as compared with synchronous radiochemotherapy.