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专业文献

25-ag捕鱼平台

文字: 2019-11-13    浏览次数:361    

purpose:vitamin d is implicated linked to liver cancer and chronic liver diseases, but its association with tumor response in hepatocellular carcinoma (hcc) patients undergoing transarterial chemoembolization (tace) remains unclear. this study aimed to determine whether vitamin d levels influence tumor response in hcc patients treated with tace.

目的:维生素d与肝癌和慢性肝病有关,但其与肝细胞癌(hcc)患者经动脉化疗栓塞(tace)后的肿瘤反应的关系尚不清楚。本研究旨在确定维生素d水平是否影响tace治疗的hcc患者的肿瘤反应。

 

methods:a total of 58 hcc patients undergoing tace were enrolled in the study. serum 25-hydroxyvitamin d (25-ohd) levels were determined at baseline and 1 day after tace using electrochemiluminescence immunoassay. response to tace was evaluated after a 4-6 week interval. univariate and multivariate analyses with cox regression model were performed to determine the risk factors associated with tumor response. receiver operating characteristic (roc) curve analysis was performed to assess the predictive performance of baseline 25-ohd levels on tumor response in hcc patients undergoing tace.

方法:共纳入58例接受tace治疗的hcc患者。采用电化学发光免疫法测定基线及tace术后1天的血清25-羟基维生素d (25-ohd)水平。间隔4-6周后评估对tace的反应。采用cox回归模型进行单因素和多因素分析,确定与肿瘤反应相关的危险因素。采用roc曲线分析评估基线25-ohd水平对行tace的hcc患者肿瘤反应的预测效果。

 

results:43.1% of hcc patients showed 25-ohd deficiency. baseline 25-ohd level was associated with liver cirrhosis (p=0.025), vascular invasion (p=0.031), barcelona clinic liver cancer stage (p=0.002) and an alanine aminotransferase increase after tace (p=0.021). serum 25-ohd level was significantly decreased 1 day after tace (p=0.045). multiple tumor numbers (p=0.034) and low baseline 25-ohd levels (p=0.040) were independently correlated with poor tumor response after tace. roc curve analysis showed that baseline 25-ohd levels present better predictive performance for or in those patients, compared with other current clinical test pointers.

结果:43.1%的hcc患者缺乏25-ohd。基线25-ohd水平与肝硬化(p = 0.025)、血管侵犯(p = 0.031)、巴塞罗那临床肝癌分期(p = 0.002)和tace术后丙氨酸转氨酶的升高(p = 0.021)有关。tace术后1天血清25-ohd水平显著降低(p = 0.045)。多个肿瘤 (p = 0.034)和低基线25-ohd水平(p = 0.040)与tace术后较差的肿瘤反应独立相关。roc曲线分析显示,与目前其他的临床试验指标相比,基线25-ohd水平对患者肿瘤客观反应(or)有着更好的预测作用。

 

conclusion:our study suggested that 25-ohd deficiency at baseline is a prognostic indicator for a poor tumor response in hepatocellular carcinoma treated with tace.

结论:我们的研究表明,基线25-ohd缺乏是肝细胞癌tace治疗后肿瘤反应差的预后指标。