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中性粒细胞/淋巴细胞比值(nlr)可以预测deb-ag捕鱼平台

文字: 2018-5-2    浏览次数:1042    

 

background:to investigate the association of ring enhancement with neutrophil to lymphocyte ratio (nlr) and the predicting values of ring enhancement and nlr for treatment response and new lesion occurrence in hepatocellular carcinoma (hcc) patients post drugeluting beads transarterial chemoembolization (debtace).

背景:研究肿瘤环形强化与nlr的关系以及肿瘤环形强化和nlr对deb-tace治疗肝细胞肝癌的疗效及新病灶发生率的预测价值。


methods: sixty-fve consecutive hcc patients received deb-tace by callispheres® were enrolled and clinical responses wereassessed by mrecist criterion. ring enhancement was assessed at 4–6 weeks and nlr was assessed within 24 hours post treatment. new lesion was evaluated atlast follow up of each patient.overall response rate (orr) was the percentage of patients achieved complete response (cr) and partial
response (pr).

方法:选择65例肝细胞癌患者应用callispheres进行deb-tace治疗,采用mrecist标准评价临床疗效。肿瘤环形强化情况在术后4 - 6周评估,nlr评估在术后24小时。每位患者随访结束时评估是否有新的病灶发生,肿瘤总缓解率(orr)是完全缓解(cr)和部分缓解(pr)患者的占比。


results: after deb-tace, cr and orr were 18.5% and 87.7%, respectively. additionally, ring enhancement was not correlated with absolute neutrophil count (anc), lymphocytes (lym) or nlr. no difference was found regarding cr, orr or new lesion between patients with or without ringenhancement. in addition, the anc of patients in cr group was lower compared tonon-cr group, and patients with lower nlrs were likely to achieve better cr and less new lesion. subgroup analysis disclosed that patients with multifocal lesions and higher barcelona clinic liver cancer (bclc) stage were of worse cr.

结果:deb-tace术后,cr和orr分别为18.5%和87.7%。环增强化与中性粒细胞数(anc)、淋巴细胞数(lym)或nlr无关。cr、orr或新病变在有无环强化的患者之间没有发现差异。此外,cr组的anc较非cr组低,nlr低的患者有可能获得更好的cr和较少发生新病灶。亚组分析显示,多发病灶和较高的巴塞罗那分期患者较难获得cr。 


conclusions: nlr but not ring enhancement post treatment could predict treatment response and new lesion occurrence of patients with hcc treated by deb-tace.
结论:nlr (中性粒细胞/淋巴细胞比值)可以预测deb-tace治疗肝细胞肝癌的疗效及新病灶的发生率,与肿瘤是否环形强化无关。